Here at Hall Analytical, we strive to deliver sector-leading product data and support to assist our customers with regulatory submissions in global markets. We’re fully committed to the continuous improvement of our analytical capabilities, through ongoing R&D projects and investment in the latest equipment for ENDS/HTP aerosol collection and analysis.
We recently introduced an advanced collection technique for analysis of metals in the aerosol generated by ENDS and HTPs to our laboratory. The collection system is called an Electrostatic Precipitator (EP) and it demonstrates significant advantages over standard filter pad collection methods.
What are the benefits of Electrostatic Precipitator (EP) systems over standard filter pad collection methods?
One of the major benefits is increased sensitivity. Metal aerosol emissions, particularly those emitted from ENDS, tend to be at very low levels. Less sensitive detection methods can result in laboratories reporting no metals detected in emissions. However, if the sensitivity of the detection method for metal analytes of concern is insufficient, then national regulators may question if the submitted data demonstrates that the product is appropriate for the protection of public health. Our preliminary testing of the EP system has demonstrated a significant reduction in target metal detection limits. We’ve also noted several major benefits of the EP system compared to standard filter pad collection. As the EP collection tube is a closed system, the potential for metal contamination is minimized compared to filter pads which require insertion and removal from the holders at the beginning and end of the aerosol collection experiment. The system set-up also enables collection without handling of the samples and allows us to collect significantly more Aerosol Collected Mass (ACM) when compared to filter pad collection. The ability to collect more ACM increases the sensitivity of the method on a per gram basis.
Why is this important?
Our clients are fully committed to supplying the highest quality reduced-risk products to markets around the world, enabling current and former smokers to switch to less harmful non-combustible nicotine-containing products. The science of ENDS and HTP analysis is constantly evolving, and our clients are keen to employ the latest analytical techniques to generate comprehensive data on their products. With the FDA’s scientific review of filed PMTAs well underway, Centre for Tobacco Products (CTP) scientists will be reviewing the quality of submitted HPHC data, including the sensitivity of analysis methods employed by the test laboratory. Hall Analytical is ready to assist with responses to any deficiency letters issued by the FDA CTP following a review of the data in your PMTA.
Find out more details below of our testing capabilities for ENDS and HTPs.